Cytochrome P-450: Structure, Mechanism, and Biochemistry by Paul Ortiz De Monetl

Description: Cytochrome P-450 by Paul Ortiz De Monetllano Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and genetics, have created a need for an up-to-date evaluation of the advances that have been made. It is hoped that this book, with its molecular focus on the cytochrome P-450 system, will alleviate this need. The authors of the individual chapters have strived to emphasize recent results without sacrificing the background required to make their chapters comprehensible to informed nonspecialists. Table of Contents 1. Metalloporphyrin Models for Cytochrome P-450.- 2. Comparison of the Peroxidase Activity of Hemeproteins and Cytochrome P-450.- 3. The Topology of the Mammalian Cytochrome P-450 Active Site.- 4. Cytochrome P-450 Reductase and Cytochrome b5 in Cytochrome P-450 Catalysis.- 5. Cytochrome P-450 Organization and Membrane Interactions.- 6. Comparative Structures of P-450 Cytochromes.- 7. Oxygen Activation and Transfer.- 8. Inhibition of Cytochrome P-450 Enzymes.- 9. Induction of Hepatic P-450 Isozymes: Evidence for Specific Receptors.- 10. Regulation of Synthesis and Activity of Cytochrome P-450 Enzymes in Physiological Pathways.- 11. Cytochrome P-450 Enzymes in Sterol Biosynthesis and Metabolism.- 12. Cytochrome P450cam and Other Bacterial P-450 Enzymes.- 13. The Crystal Structure of Cytochrome P450cam.- Appendix. Rat Hepatic Cytochrome P-450: Comparative Study of Multiple Isozymic Forms. Promotional Springer Book Archives Long Description Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de Details ISBN1475799411 Publisher Springer-Verlag New York Inc. Year 2013 ISBN-10 1475799411 ISBN-13 9781475799415 Format Paperback Publication Date 2013-04-30 Imprint Springer-Verlag New York Inc. Subtitle Structure, Mechanism, and Biochemistry Place of Publication New York, NY Country of Publication United States DEWEY 571.6 Short Title CYTOCHROME P-450 SOFTCOVER REP Language English Media Book Pages 556 Illustrations X, 556 p. AU Release Date 2013-04-30 NZ Release Date 2013-04-30 US Release Date 2013-04-30 UK Release Date 2013-04-30 Author Paul Ortiz De Monetllano Edition Description Softcover reprint of the original 1st ed. 1986 Alternative 9780306421471 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96312661;

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