Cytochrome P450: Structure, Mechanism, and Biochemistry by Paul R. Ortiz de Mont

Description: Cytochrome P450 by Paul R. Ortiz de Montellano Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years. Back Cover In this third edition of Cytochrome P450: Structure, Mechanism, and Biochemistry, Dr. Paul Ortiz de Montellano has brought together a group of new authors as well as authors from previous editions to produce a timely volume that will be of considerable interest to a broad array of P450 researchers. The explosion of discovery of CYP (cytochrome P450) genes through genome analysis--more than 3500 to date--provides the more than 10,000 scientists around the world who study these monooxygenases a rich source of interesting and important research problems. Many have remained central elements over the 18 years that span the three editions of this book, including mechanisms of catalysis, oxygen activation and inhibition, gene regulation, and P450 structure. Each new edition updates our knowledge of such central issues in the study of P450s, emphasizing the timeliness of this newest volume. In this newest edition, we find that the newest discussion of P450 structure includes information of bacterial (soluble) P450s interwoven with that of eukaryotic (membrane bound) of this superfamily, highlighting the newest developments in this area. The complete battery of human P450s is now known and summarized in the new edition. In addition, general overviews of plant P450s and those from microbes contained within this newest edition provide a broader view of P450 diversity than seen in earlier editions. Each of these three editions should be on bookshelves of laboratories studying P450s. The third edition of Cytochrome P450: Structure, Mechanism, and Biochemistry provides an opportunity to judge progress in many key areas of P450 research while at the same time learn of new directions in the field. It is an excellent and most useful volume. Dr. Michael R. Waterman, Ph.D., Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN The third edition of Cytochrome P450: Structure, Mechanism, and Biochemistry provides an exceptionally fine summary of our present knowledge of the remarkable hemoprotein often called "natures most versatile biological catalyst." Edited by Paul Ortiz de Montellano, with chapters by many of the worlds experts in this rapidly developing field, this edition includes major advances in the past decade such as the crystal structure of membrane-bound forms of the enzyme and evidence for multiple species of activated oxygen, based in part on the use of radical clocks and computational approaches. The sequences of several thousand P450s are now known, and recent progress in understanding the properties and functions of those in the microbial and plant worlds, as well as the better known mammalian isozymes, is now included. The versatility of cytochrome P450 includes the ability to metabolize innumerable substrates of both physiological and xenobiotic importance, and to be markedly altered in activity by a wide variety of inducers and inhibitors. Accordingly, this new edition will be invaluable to scientists in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology, and toxicology. M. J. Coon, Victor C. Vaughan Distinguished University Professor of Biological Chemistry, Emeritus, The University of Michigan Medical School, Ann Arbor, MI Table of Contents Models and Mechanisms of Cytochrome P450 Action.- Computational Approaches to Cytochrome P450 Function.- Structures of Cytochrome P450 Enzymes.- Electron Transfer Partners of Cytochrome P450.- Activation of Molecular Oxygen by Cytochrome P450.- Substrate Oxidation by Cytochrome P450 Enzymes.- Inhibition of Cytochrome P450 Enzymes.- Induction of Cytochrome P450 Enzymes.- Hormonal Regulation of Liver Cytochrome P450 Enzymes.- Human Cytochrome P450 Enzymes.- Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids.- Cytochrome P450s in Plants.- The Diversity and Importance of Microbial Cytochromes P450. Review Praise for the Second Edition: `Professor Paul R. Ortiz de Montellano (known in some databases as P.R.O. Demontellano has spared no effort in the preparation of this major work. All 15 chapters and the two appendices were written by experts of high international reputation. The content is structured into four parts arranged clearly and logically. As a result, the reader goes from the table of contents to the main body of the book with a favourable impression of clarity and comprehensiveness. Needless to say, this impression is verified throughout the chapters. ISSX: International Society for Study of Xenobiotics (October 1996) `The 1986 edition of Cytochrome P450: Structure, Mechanism, and Biochemistry is probably the most frequently cited single source of information about the subject...Ortiz de Montellano has now produced a second edition with 15 new chapters. In myestimation, he has again succeeded in bringing the P450 field into sharp focus. Science, 271 (March 1996) Long Description Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years. Review Text Praise for the Second Edition: Professor Paul R. Ortiz de Montellano (known in some databases as P.R.O. Demontellano has spared no effort in the preparation of this major work. All 15 chapters and the two appendices were written by experts of high international reputation. The content is structured into four parts arranged clearly and logically. As a result, the reader goes from the table of contents to the main body of the book with a favourable impression of clarity and comprehensiveness. Needless to say, this impression is verified throughout the chapters. ISSX: International Society for Study of Xenobiotics (October 1996) The 1986 edition of Cytochrome P450: Structure, Mechanism, and Biochemistry is probably the most frequently cited single source of information about the subject...Ortiz de Montellano has now produced a second edition with 15 new chapters. In my estimation, he has again succeeded in bringing the P450 field into sharp focus. Science, 271 (March 1996) Review Quote Praise for the Second Edition: Professor Paul R. Ortiz de Montellano (known in some databases as P.R.O. Demontellano has spared no effort in the preparation of this major work. All 15 chapters and the two appendices were written by experts of high international reputation. The content is structured into four parts arranged clearly and logically. As a result, the reader goes from the table of contents to the main body of the book with a favourable impression of clarity and comprehensiveness. Needless to say, this impression is verified throughout the chapters. ISSX: International Society for Study of Xenobiotics (October 1996) The 1986 edition of Cytochrome P450: Structure, Mechanism, and Biochemistry is probably the most frequently cited single source of information about the subject...Ortiz de Montellano has now produced a second edition with 15 new chapters. In my estimation, he has again succeeded in bringing the P450 field into sharp focus. Science, 271 (March 1996) Details ISBN0306483246 Language English Edition 3rd ISBN-10 0306483246 ISBN-13 9780306483240 Media Book Format Hardcover DEWEY 572.7 Year 2004 Subtitle Structure, Mechanism, and Biochemistry Imprint Kluwer Academic/Plenum Publishers Place of Publication New York Country of Publication United States Short Title CYTOCHROME P450 2005/E 3/E Pages 690 Edited by Paul R. Ortiz de Montellano Replaced by 9783319121079 DOI 10.1007/b114441;10.1007/b139087;10.1007/978-0-387-27447-8 AU Release Date 2004-12-21 NZ Release Date 2004-12-21 US Release Date 2004-12-21 UK Release Date 2004-12-21 Author Paul R. Ortiz de Montellano Publisher Springer Science+Business Media Edition Description 3rd ed. 2005 Publication Date 2004-12-21 Alternative 9781441934437 Illustrations XX, 690 p. Audience General We've got this At The Nile, if you're looking for it, we've got it. 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