Cytochrome P450: Structure, Mechanism, and Biochemistry by Paul R. Ortiz de Mont

Description: Cytochrome P450 by Paul R. Ortiz de Montellano This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems.Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology. FORMAT Paperback LANGUAGE English CONDITION Brand New Back Cover This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology. Author Biography Paul R. Ortiz de Montellano received his PhD in bioorganic chemistry from Harvard University, Cambridge, MA. After postdoctoral work as a North Atlantic Treaty Organization Fellow in ZÜrich, Switzerland, and a stint with Syntex in Mexico City and Palo Alto, California, he joined the faculty of the University of California in San Francisco, where he is currently Professor, Vice-chair of the Department of Pharmaceutical Chemistry, and Associate Dean for Research of the School of Pharmacy. His research interests center on the structure, mechanism, inhibition, and biochemistry of hemoproteins, including the cytochrome P450 enzymes. He has received the B.B. Brodie Award in Drug Metabolism from the American Society of Pharmacology and Experimental Therapeutics, the R.T. Williams Distinguished Scientific Achievement Award from the International Society for the Study of Xenobiotics, and the Ernest H. Volwiler Research Achievement Award from the American Association of Colleges of Pharmacy. Table of Contents Volume 1.- 1 Structures of Cytochrome P450 Enzymes.- 2 Electron Transfer Partners of Cytochrome P450.- 3 Activation of Molecular Oxygen in Cytochromes P450.- 4 Substrate Oxidation by Cytochrome P450 Enzymes.- 5 Inhibition of Cytochrome P450 Enzymes.- 6 Microbial Cytochromes P450.- 7 P450s in Plants, Insects and their Fungal Pathogens.- 8 P450 Biotechnology.- Volume 2.- 9 Human Cytochrome P450 Enzymes.- 10 Nuclear Receptor-Mediated Regulation of Cytochrome P450 Genes.- 11 Hormonal Regulation of Liver Cytochrome P450 Enzymes.- 12 P450 Enzymes in Steroid Processing.- 13 P450 Enzymes in Lipid Oxidation. Feature Two-volume Fourth Edition updated with the most cutting-edge research Explores the advances of the past decade on the structure, mechanism, and biochemistry of cytochrome P450 enzymes Discusses structure and role of cytochrome P450 in biology Details ISBN3319374370 Year 2016 ISBN-10 3319374370 ISBN-13 9783319374376 Format Paperback Language English Media Book DEWEY 572 Imprint Springer International Publishing AG Subtitle Structure, Mechanism, and Biochemistry Place of Publication Cham Country of Publication Switzerland Edited by Paul R. Ortiz de Montellano Pages 912 Publication Date 2016-10-08 Short Title Cytochrome P450 Edition 4th UK Release Date 2016-10-08 Author Paul R. Ortiz de Montellano Birth 1965 Affiliation Marquette University, Wisconsin Position EDFR Qualifications M.D. Publisher Springer International Publishing AG Edition Description Softcover reprint of the original 4th ed. 2015 Alternative 9783319121079 Audience Professional & Vocational Illustrations 80 Illustrations, color; 163 Illustrations, black and white; X, 912 p. 243 illus., 80 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:131026563;

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