Genetic Mosaics and Chimeras in Mammals by L.B. Russell (English) Paperback Book

Description: Genetic Mosaics and Chimeras in Mammals by L.B. Russell Liane B. Russell Biology Division, Oak Ridge National Laboratory Oak Ridge, TN 37830 Composite individuals have always excited mankinds imaginaÂ tion. Even the earliest recorded mythologies are full of fanciful examples of creatures such as centaurs, mermaids, androgynes, and winged horses. While real, naturally occurring, mosaics might not appear as spectacular to the popular mind, their study — particuÂ larly in Drosophila and plants — has made important contributions to genetics, starting relatively early in this century. In mammals, too, examples of mosaics resulting from early or late somatic mutaÂ tions and from abnormal egg maturation and/or fertilization events have been known since the 1930s and exploited for the information they could provide on such subjects as the or1g1n of the germline and the extent of cell mixing (see Russell 1964). Two major, and unrelated, advances, both published 17 years ago, suddenly provided a wealth of material for the study of mamÂ malian mosaicism. One was the successful manipulation of early embryos to make viable aggregation chimeras (Tarkowski 1961; Mintz 1962) — a feat made possible by earlier advances in embryo culture and transfer. The other was the hypothesis that only one X chromoÂ some of a mammal is active (Lyon 1961; Russell 1961) and that, by virtue of the fact that the choice of the active X is made at ranÂ dom early in development, the normal mammalian female is a mosaic for any X-linked genetic heterozyg FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Liane B. Russell Biology Division, Oak Ridge National Laboratory Oak Ridge, TN 37830 Composite individuals have always excited mankinds imagina- tion. Even the earliest recorded mythologies are full of fanciful examples of creatures such as centaurs, mermaids, androgynes, and winged horses. While real, naturally occurring, mosaics might not appear as spectacular to the popular mind, their study -- particu- larly in Drosophila and plants -- has made important contributions to genetics, starting relatively early in this century. In mammals, too, examples of mosaics resulting from early or late somatic muta- tions and from abnormal egg maturation and/or fertilization events have been known since the 1930s and exploited for the information they could provide on such subjects as the or1g1n of the germline and the extent of cell mixing (see Russell 1964). Two major, and unrelated, advances, both published 17 years ago, suddenly provided a wealth of material for the study of mam- malian mosaicism.One was the successful manipulation of early embryos to make viable aggregation chimeras (Tarkowski 1961; Mintz 1962) -- a feat made possible by earlier advances in embryo culture and transfer. The other was the hypothesis that only one X chromo- some of a mammal is active (Lyon 1961; Russell 1961) and that, by virtue of the fact that the choice of the active X is made at ran- dom early in development, the normal mammalian female is a mosaic for any X-linked genetic heterozygosity. Table of Contents Use of Chimeras and Cell Aggregations to Study Developmental Potency, Gene Expression, Control of Phenotype, and Tumor Origin.- Reversion of malignancy and normalized differentiation of teratocarcinoma cells in chimeric mice.- Viable chimeras produced from normal and parthenogenetic mouse embryos.- Ovarian teratomas in mice are derived from oocytes that have completed the first meiotic division.- Growth control in chimeras.- Attempts at locating the site of action of genes affecting behavior.- Fine structure of cells in embryos chimeric for mutant genes at the T/t locus.- An analysis of differentiation in coaggregation cultures between mouse neuronal and tumor cells.- The use of mosaics and experimental chimeras to study the pathogenesis of neoplasia.- Antibodies to allozymes as potential cell markers for chimeric mouse studies.- Use of Chimeras and Mutational or Disjunctional Mosaics to Study Gamete Differentiation, Sexual Development, and Origin of the Germline.- Reproduction in single-sex chimeras.- Germ cells in XX ? XY mouse chimeras.- Use of the sex reversed gene (Sxr) to investigate functional sex reversal and gonadal determination in mammals.- Why not androgynes among mammals?.- Cell interactions in the sex organs of sex reversed mice heterozygous for testicular feminization.- Spontaneous sex mosaicism in BALB/cWt mice.- Evidence from mutable genes concerning the origin of the germ line.- X Chromosome Inactivation and Derepression.- Bimodal distribution of ?-galactosidase activities in mouse embryos.- Biochemical studies on X-chromosome activity in preimplantation mouse embryos.- Hypoxanthine guanine phosphoribosyl transferase expression in early mouse development.- The direct demonstration of an X-chromosome dosage effect prior to inactivation.- Use ofteratocarcinoma stem cells as a model system for the study of X-chromosome inactivation in vitro.- The stability of X-chromosome inactivation: studies with mouse-human cell hybrids and mouse teratocarcinomas.- Studies of human-mouse cell hybrids with respect to X-chromosome inactivation.- X-Chromosome Nonrandomness: Imprinting, Selection.- Preferential inactivation of the paternally derived X chromosome in mice.- Preferential expression of the maternally derived X chromosome in extraembryonic tissues of the mouse.- In search of nonrandom X inactivation: studies of the placenta from newborns heterozygous for glucose-6-phosphate dehydrogenase.- The use of mouse X-autosome translocations in the study of X-inactivation pathways and nonrandomness.- Selection and cell communication as determinants of female phenotype.- Mathematical and Statistical Analyses of Mosaic Patterns.- Clonal growth versus cell mingling.- Combinatorial and computer analysis of random mosaics.- Data analysis of four X-chromosome inactivation experiments. Promotional Springer Book Archives Long Description Liane B. Russell Biology Division, Oak Ridge National Laboratory Oak Ridge, TN 37830 Composite individuals have always excited mankinds imagina Details ISBN146843392X Short Title GENETIC MOSAICS & CHIMERAS IN Series Basic Life Sciences Language English ISBN-10 146843392X ISBN-13 9781468433920 Media Book Format Paperback Series Number 12 Year 2012 Publication Date 2012-06-14 Imprint Springer-Verlag New York Inc. Place of Publication New York, NY Country of Publication United States Edited by L. B. Russell Pages 485 Illustrations XIV, 485 p. DOI 10.1007/978-1-4684-3390-6 AU Release Date 2012-06-14 NZ Release Date 2012-06-14 US Release Date 2012-06-14 UK Release Date 2012-06-14 Author L.B. Russell Publisher Springer-Verlag New York Inc. Edition Description Softcover reprint of the original 1st ed. 1978 Alternative 9780306400650 DEWEY 599.0151 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96394636;

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