Description: Leucocyte Trafficking Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). The Role of Fucosyltransferases and Selectins Author(s): A. Hamann, Khusru Asadullah, A. Schottelius Format: Paperback Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Germany Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K ISBN-13: 9783662053997, 978-3662053997 Synopsis An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.
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Book Title: Leucocyte Trafficking
Number of Pages: 242 Pages
Language: English
Publication Name: Leucocyte Trafficking: the Role of Fucosyltransferases and Selectins
Publisher: Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
Publication Year: 2013
Subject: Medicine, Biology, Psychiatry
Item Height: 210 mm
Item Weight: 339 g
Type: Textbook
Author: Khusru Asadullah, A. Hamann, A. Schottelius
Series: Ernst Schering Foundation Symposium Proceedings
Item Width: 148 mm
Format: Paperback
