MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers by Takahir

Description: MicroRNAs by Takahiro Ochiya, Ryou-U Takahashi MicroRNAs (miRNAs) constitute a large family of small, approximately 20-22-nucleotide, non-coding RNAs that are involved in gene regulation, mainly at the post-transcriptional level. Multiple lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are involved in the onset of many diseases, including cancer. In various types of cancer, miRNAs play important roles in tumor initiation and development. Recently, miRNAs have been demonstrated to also be secreted via small endosome-derived vesicles called exosomes--which are derived from multiple cell types--including immunocytes and cancer cells. Exosomal miRNAs exert important functions in cell-to-cell communication and have been investigated as prognostic and diagnostic biomarkers.This Special Issue of the Journal of Clinical Medicine will cover the following important aspects of miRNA functions in cancer biology: - Biosynthesis of miRNA and its roles in gene regulation;- Roles of miRNA in cancer biology, including1) Roles of miRNA in tumor initiation and development, 2) Roles of miRNA in drug resistance, 3) Roles of miRNA in metastasis;- Therapeutic potential of miRNAs for cancer therapy;- Roles of circulating miRNAs in cancer development;- Expression levels/profiles of body fluid miRNAs for cancer diagnosis, prognosis, and therapeutic responses;-Novel and efficient miRNA delivery methods and their applications in cancer therapy. FORMAT Paperback LANGUAGE English CONDITION Brand New Long Description MicroRNAs (miRNAs) constitute a large family of small, approximately 20-22-nucleotide, non-coding RNAs that are involved in gene regulation, mainly at the post-transcriptional level. Multiple lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are involved in the onset of many diseases, including cancer. In various types of cancer, miRNAs play important roles in tumor initiation and development. Recently, miRNAs have been demonstrated to also be secreted via small endosome-derived vesicles called exosomes--which are derived from multiple cell types--including immunocytes and cancer cells. Exosomal miRNAs exert important functions in cell-to-cell communication and have been investigated as prognostic and diagnostic biomarkers. This Special Issue of the Journal of Clinical Medicine will cover the following important aspects of miRNA functions in cancer biology: - Biosynthesis of miRNA and its roles in gene regulation; - Roles of miRNA in cancer biology, including 1) Roles of miRNA in tumor initiation and development, 2) Roles of miRNA in drug resistance, 3) Roles of miRNA in metastasis; - Therapeutic potential of miRNAs for cancer therapy; - Roles of circulating miRNAs in cancer development; - Expression levels/profiles of body fluid miRNAs for cancer diagnosis, prognosis, and therapeutic responses; -Novel and efficient miRNA delivery methods and their applications in cancer therapy. Details ISBN3038972525 Author Ryou-U Takahashi ISBN-10 3038972525 ISBN-13 9783038972525 Format Paperback Pages 272 Language English Year 2018 Publication Date 2018-10-11 Imprint Mdpi AG Subtitle Novel Biomarkers and Therapeutic Targets for Human Cancers Illustrations 64 Illustrations Short Title Micrornas UK Release Date 2018-10-11 Publisher Mdpi AG Audience General We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:131022957;

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