Description: RNA Sequence, Structure, and Function: Computational and Bioinformatic Methods by Jan Gorodkin, Walter L. Ruzzo The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950s, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950s, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNAs ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In RNA Sequence, Structure, Function: Computational and Bioinformatic Methods, expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in more detailed aspects of the algorithms. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results. Thorough and intuitive, RNA Sequence, Structure, Function: Computational and Bioinformatic Methods aids scientists in continuing to study key methods and principles of RNA bioinformatics. Back Cover The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950s, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNAs ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In RNA Sequence, Structure, Function: Computational and Bioinformatic Methods , expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in more detailed aspects of the algorithms. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results. Thorough and intuitive, RNA Sequence, Structure, Function: Computational and Bioinformatic Methods aids scientists in continuing to study key methods and principles of RNA bioinformatics. Table of Contents Concepts and Introduction to RNA Bioinformatics.- The Principles of RNA Structure Architecture.- The Determination of RNA Folding Nearest Neighbor Parameters.- Energy Directed RNA Structure Prediction.- Introduction to Stochastic Context Free Grammars.- An Introduction to RNA Databases.- Energy-based RNA Consensus Secondary Structure Prediction in Multiple Sequence Alignments.- SCFGs in RNA Secondary Structure Prediction: A Hands-on Approach.- Annotating Functional RNAs in Genomes using Infernal.- Class-specific Prediction of ncRNAs.- Abstract Shape Analysis of RNA.- Introduction to RNA Secondary Structure Comparison.- RNA Structural Alignments, Part I: Sankoff Based Approaches for Structural Alignments.- RNA Structural Alignments, Part II: Non-Sankoff Approaches for Structural Alignments.- De novo Discovery of Structured ncRNA Motifs in Genomic Sequences.,- Phylogeny and Evolution of RNA Structure.- The Art of Editing RNA Structural Alignments.- Automated Modeling of RNA 3D Structure.- Computational Prediction of RNA-RNA Interactions.- Computational Prediction of microRNA Genes.- MicroRNA Target Finding by Comparative Genomics.- Bioinformatics of siRNA Design.- RNA-protein Interactions: An Overview. Review From the book reviews:"This book on RNA structure and function is suitable for both graduate and post-graduate students as well as established researchers. … the book is also a valuable review of the state of the art of hot topics on cutting edge directions of research. In addition, the value of each chapter is enriched by an extensive set of references of recent yet established papers, offering a reliable starting point for literature on each research topic." (Irina Ioana Mohorianu, zbMATH 1307.92008, 2015) Review Quote From the book reviews: "This book on RNA structure and function is suitable for both graduate and post-graduate students as well as established researchers. ... the book is also a valuable review of the state of the art of hot topics on cutting edge directions of research. In addition, the value of each chapter is enriched by an extensive set of references of recent yet established papers, offering a reliable starting point for literature on each research topic." (Irina Ioana Mohorianu, zbMATH 1307.92008, 2015) Feature Presents current up-to-date methodologies Features tips on trouble shooting and avoiding known pitfalls Contains key notes and implementation advice from the experts Details ISBN162703708X Short Title RNA SEQUENCE STRUCTURE & FUNCT Language English ISBN-10 162703708X ISBN-13 9781627037082 Media Book Format Hardcover Series Number 1097 Imprint Humana Press Inc. Place of Publication Totowa, NJ Country of Publication United States Edited by Walter L. Ruzzo Year 2014 Publication Date 2014-03-18 Pages 533 Edition 2014th DOI 10.1007/978-1-62703-709-9 UK Release Date 2014-03-18 AU Release Date 2014-03-18 NZ Release Date 2014-03-18 US Release Date 2014-03-18 Author Walter L. Ruzzo Publisher Humana Press Inc. Edition Description 2014 ed. Series Methods in Molecular Biology Alternative 9781493961658 DEWEY 572.88 Audience Postgraduate, Research & Scholarly Illustrations 46 Illustrations, color; 74 Illustrations, black and white; XI, 533 p. 120 illus., 46 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96374640;
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ISBN-13: 9781627037082
Book Title: RNA Sequence, Structure, and Function: Computational and Bioinfor
Number of Pages: 533 Pages
Language: English
Publication Name: Rna Sequence, Structure, and Function: Computational and Bioinformatic Methods
Publisher: Humana Press Inc.
Publication Year: 2014
Subject: Engineering & Technology, Biology
Item Height: 254 mm
Type: Textbook
Author: Jan Gorodkin, Walter L. Ruzzo
Item Width: 178 mm
Format: Hardcover
