Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use

Description: Treatment and Prevention of Malaria by Henry M. Staines, Sanjeev Krishna Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail. Notes Gives a comprehensive account of the recent advances in anti-malaria drugsChapters contributed by expert authorsDescribes new ideas and directions for study Back Cover Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail. Table of Contents Antimalarial drugs and the control and elimination of malaria.- 4-Aminoquinolines: chloroquine, amodiaquine and next generation analogues.- Cinchona alkaloids: quinine and quinidine.- 8-Aminoquinolines: primaquine and tafenoquine.- Other 4-methanolquinolines, amyl alcohols and phentathrenes: mefloquine, lumefantrine, halofantrine, piperaquine and pyronaridine.- Antifolates: pyrimethamine, proguanil, sulphadoxine and dapsone.- Naphthoquinones: atovaquone, and other antimalarials targeting mitochondrial functions.- Non-antifolate antibiotics: clindamycin, doxycycline, azithromycin and fosmidomycin.- Artemisinins: artemisinin, dihydroartemisinin, artemether, arteether and artesunate.- Second generation peroxides: the OZs and artemisone.- Combination therapy in light of emerging artemisinin resistance.- New medicines to combat malaria: an overview of the global pipeline of therapeutics.- Molecular markers of Plasmodium resistance to antimalarials.- Prevention of malaria.- Malaria diagnostics: lighting the path. Review From the reviews:"Staines and Krishna successfully captures the essence of what we know about antimalarials at the beginning of the second decade of the 21st century. … the book is a welcome and highly valuable documentation on where we stand and offers valuable food for thought in the search for the way forward." (Martin P. Grobusch, Trends in Parasitology, September, 2012) Review Quote From the reviews:Staines and Krishna successfully captures the essence of what we know about antimalarials at the beginning of the second decade of the 21st century. … the book is a welcome and highly valuable documentation on where we stand and offers valuable food for thought in the search for the way forward. (Martin P. Grobusch, Trends in Parasitology, September, 2012) Feature Gives a comprehensive account of the recent advances in anti-malaria drugs Chapters contributed by expert authors Describes new ideas and directions for study Details ISBN3034604793 Publisher Birkhauser Verlag AG Series Milestones in Drug Therapy ISBN-10 3034604793 ISBN-13 9783034604796 Format Hardcover Imprint Birkhauser Verlag AG Place of Publication Basel Country of Publication Switzerland Edited by Sanjeev Krishna DEWEY 616.9362 Year 2012 Edition 2012th Short Title TREATMENT & PREVENTION OF MALA Edition Description 2012 Language English Media Book Subtitle Antimalarial Drug Chemistry, Action and Use Pages 318 DOI 10.1007/978-3-0346-0480-2 UK Release Date 2012-01-06 Publication Date 2012-01-06 Illustrations X, 318 p. Author Sanjeev Krishna Alternative 9783034808088 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. 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